drug-discovery-prompts/upstream/K-Dense-AI-scientific-agent-skills/skills/database-lookup/references/drugbank.md

title, task, lineage_type, upstream_source, upstream_sha, imported_at, prompt_class, upstream_changes, author, validated

title	task	lineage_type	upstream_source	upstream_sha	imported_at	prompt_class	upstream_changes	author	validated
DrugBank API		import	https://github.com/K-Dense-AI/scientific-agent-skills/blob/9c9bd2e9/skills/database-lookup/references/drugbank.md	9c9bd2e9	2026-06-26	prompt	accepted	upstream	false

DrugBank API

Important: DrugBank's full API is commercial (paid license required)

Free alternatives for drug data:

• ChEMBL — extensive bioactivity data, free API
• PubChem — free compound data
• OpenFDA — drug labels, adverse events
• DGIdb (https://dgidb.org/api) — drug-gene interactions, free

Base URL (Paid API)

https://api.drugbank.com/v1

Auth

API key required: Authorization: Bearer <api_key>

Key Endpoints (Paid API)

Endpoint	Description
/drugs/{drugbank_id}	Get drug by DrugBank ID
/drugs?q={query}	Search drugs
/drugs/{id}/interactions	Drug-drug interactions
/drugs/{id}/targets	Drug targets
/drugs/{id}/enzymes	Metabolizing enzymes
/drugs/{id}/pathways	Associated pathways
/drugs/{id}/adverse_effects	Adverse effects
/drug_interactions?drugbank_id={id1},{id2}	Check specific interactions

Example Calls

GET /drugs/DB00945  (aspirin)
GET /drugs?q=aspirin
GET /drugs/DB00945/interactions
GET /drugs/DB00945/targets

Response Format

{
  "drugbank_id": "DB00945",
  "name": "Acetylsalicylic acid",
  "cas_number": "50-78-2",
  "groups": ["approved"],
  "targets": [{"name": "Prostaglandin G/H synthase 1", "uniprot_id": "P23219", "gene_name": "PTGS1", "actions": ["inhibitor"]}],
  "external_ids": {"chembl": "CHEMBL25", "pubchem_compound": "2244"}
}

Free Access Options

• DrugBank Open Data: ~2,500 FDA-approved drugs as XML/CSV download from https://go.drugbank.com/releases/latest
• Academic License: Free for non-commercial use, provides data downloads (not API)